Entrepreneurship is vital to the success of tourism and hospitality and the sector makes an important contribution to many island economies. Despite this, far too little attention has been paid by researchers to tourism and hospitality entrepreneurship in islands (THEI). This research helps to address this gap through a systematic review of the literature, conducted to provide a platform for further research and to help investigators set their research priorities. Using the Scopus database and the PRISMA technique, a total of 132 articles were included in bibliometric and thematic content analyses. Although there has been an increase in THEI research, this has tended to focus on the Asia-Pacific region. It is suggested that researchers consider redressing this geographical bias and conduct more quantitative and comparative THEI studies. Further opportunities exist to investigate the characteristics and behaviors of island entrepreneurs and the impacts of the industrial and spatial aspects of THEI.